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The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer.

作者信息

Almeida A, Muleris M, Dutrillaux B, Malfoy B

机构信息

CNRS URA 620, Institut Curie, Section de Biologie, Paris, France.

出版信息

Genes Chromosomes Cancer. 1994 Sep;11(1):63-5. doi: 10.1002/gcc.2870110110.

DOI:10.1002/gcc.2870110110
PMID:7529048
Abstract

We report the amplification and overexpression of the IGFIR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.

摘要

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