Adélaïde J, Penault-Llorca F, Dib A, Yarden Y, Jacquemier J, Birnbaum D
Laboratoire de Biologie des Tumeurs, Institut Paoli-Calmettes, Marseille, France.
Genes Chromosomes Cancer. 1994 Sep;11(1):66-9. doi: 10.1002/gcc.2870110111.
The Heregulin (HGL) gene, encoding a ligand for a member of the ERBB receptor family, is located at 8p12-p22, in or close to a region frequently amplified in breast carcinoma. Amplification of HGL was detected in three of 83 (3.6%) cases of breast tumors. No overexpression of the gene was observed in the amplified tumors. This and the low incidence of amplification suggest that HGL is not the key gene of the 8p12 amplification but may be used as a marker of large amplification units.
这里生长调节因子（HGL）基因编码ERBB受体家族成员的一种配体，定位于8p12 - p22，位于乳腺癌中经常扩增的一个区域内或附近。在83例乳腺肿瘤中有3例（3.6%）检测到HGL扩增。在扩增的肿瘤中未观察到该基因的过表达。这种情况以及扩增的低发生率表明，HGL不是8p12扩增的关键基因，但可能用作大扩增单元的标志物。
