Spohr H L, Willms J, Steinhausen H C
Department of Pediatrics, Rittberg Hospital of the German Red Cross, Berlin.
Acta Paediatr Suppl. 1994 Nov;404:19-26. doi: 10.1111/j.1651-2227.1994.tb13379.x.
At present, alcohol is recognized as the leading teratogenic agent in long-lasting CNS dysfunction. Little is known about the long-term development and outcome of children with fetal alcohol syndrome (FAS). Forty-four FAS patients who were diagnosed in early childhood were followed up for 10-14 years. This study documents the developmental changes of the manifestations of FAS from childhood to adolescence and describes a characteristic "juvenile" pattern of FAS, which may help to identify this syndrome even in adolescence. This is especially relevant for patients who were not diagnosed earlier.
目前，酒精被认为是导致长期中枢神经系统功能障碍的主要致畸剂。关于胎儿酒精综合征（FAS）患儿的长期发育和预后知之甚少。对44名在幼儿期被诊断为FAS的患者进行了10至14年的随访。本研究记录了FAS表现从儿童期到青春期的发育变化，并描述了FAS一种特征性的“青少年”模式，这可能有助于即使在青春期也能识别该综合征。这对于早期未被诊断的患者尤为重要。
