Osonoe K, Mori N, Suzuki K, Osonoe M
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Brain Res. 1994 Nov 14;663(2):338-40. doi: 10.1016/0006-8993(94)91283-1.
The effects of intraperitoneal NG-methyl-L-arginine and N omega-nitro-L-arginine methyl ester, specific inhibitors of nitric oxide (NO) synthase, were examined on the pentylenetetrazol (PTZ)-induced seizures in rats. The incidence and latency for the onset of myoclonic jerks, clonic seizures, and tonic generalized extension were observed as specific parameters among PTZ-induced seizures. Both drugs preferentially suppressed the tonic generalized extension and prolonged the latency for the onset of each parameter, suggesting NO has a significant effect on the PTZ-induced seizure.
研究了一氧化氮（NO）合酶的特异性抑制剂——腹腔注射NG-甲基-L-精氨酸和Nω-硝基-L-精氨酸甲酯对大鼠戊四氮（PTZ）诱发癫痫发作的影响。观察了肌阵挛性抽搐、阵挛性发作和强直性全身伸展发作的发生率和发作潜伏期，作为PTZ诱发癫痫发作的具体参数。两种药物均优先抑制强直性全身伸展，并延长每个参数发作的潜伏期，表明NO对PTZ诱发的癫痫发作有显著影响。
