Mizutani A, Saito H, Abe K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Brain Res. 1993 Mar 12;605(2):309-11. doi: 10.1016/0006-8993(93)91756-i.
Effects of NO synthase inhibitors on long-term potentiation (LTP) were investigated in the dentate gyrus of anesthetized rats. Administration of NG-nitro-L-arginine methyl ester (L-NAME; 50 nmol i.c.v.) greatly blocked the generation of LTP without affecting basal responses. NG-nitro-L-arginine (50 nmol) or NG-methyl-L-arginine (50 nmol) also showed similar effects. The LTP-blocking effect of L-NAME was reversed by coadministration of L-arginine (500 nmol). These results suggest that NO participates in the generation of LTP at the dentate gyrus in vivo.
在麻醉大鼠的齿状回中研究了一氧化氮合酶抑制剂对长时程增强（LTP）的影响。腹腔注射NG-硝基-L-精氨酸甲酯（L-NAME；50 nmol）可显著阻断LTP的产生，而不影响基础反应。NG-硝基-L-精氨酸（50 nmol）或NG-甲基-L-精氨酸（50 nmol）也显示出类似的效果。同时给予L-精氨酸（500 nmol）可逆转L-NAME对LTP的阻断作用。这些结果表明，一氧化氮在体内参与了齿状回中LTP的产生。
