Sutedja G, van Kralingen K, Schramel F M, Postmus P E
Department of Pulmonary Medicine, Free University Hospital, Amsterdam, The Netherlands.
Thorax. 1994 Dec;49(12):1243-6. doi: 10.1136/thx.49.12.1243.
Obstruction of a major airway by tumour causes serious morbidity. There is still scope for a widely applicable, simple and effective treatment to provide rapid palliation.
A fibreoptic bronchoscope prototype with an insulated inner sheath was used under local anaesthesia in 17 patients with locally advanced tracheobronchial malignancies. An insulated flexible electro-surgery probe was used to coagulate intraluminal tumour mass using standard electrosurgery equipment.
Immediate reopening of the airway was obtained in 15 of the 17 patients. Two appeared to have extraluminal disease. Eleven patients had an obvious bronchoscopic response in whom a > 75% reopening of the normal airway diameter was achieved. Eight patients had subjective improvement of their dyspnoea, but only in four cases was there an objective improvement in physiological parameters. Haemoptysis resolved in four. There were no deaths resulting from treatment. Minor bleeding occurred in one patient and an aspiration pneumonia occurred in one. Three patients received additional treatment.
Fibreoptic bronchoscopic electrosurgery is a simple technique for rapid palliation and immediate tumour debulking in patients with central tracheobronchial tumours. Further work is needed to compare its efficacy with other techniques.
肿瘤导致的大气道阻塞会引发严重的发病率。对于提供快速缓解的广泛适用、简单有效的治疗方法仍有发展空间。
在局部麻醉下,对17例局部晚期气管支气管恶性肿瘤患者使用了带有绝缘内鞘的纤维支气管镜原型。使用绝缘柔性电外科探头,通过标准电外科设备凝固腔内肿瘤块。
17例患者中有15例气道立即重新开通。2例似乎有腔外病变。11例患者有明显的支气管镜反应,正常气道直径重新开通>75%。8例患者的呼吸困难主观上有所改善,但只有4例患者的生理参数有客观改善。4例咯血症状得到缓解。治疗未导致死亡。1例患者出现轻微出血,1例发生吸入性肺炎。3例患者接受了额外治疗。
纤维支气管镜电外科手术是一种简单的技术,可用于中央气管支气管肿瘤患者的快速缓解和立即肿瘤减积。需要进一步开展工作以将其疗效与其他技术进行比较。