循环病毒粒子RNA和细胞相关病毒DNA的周转反映了1型人类免疫缺陷病毒感染个体中的活跃病毒复制。
Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals.
作者信息
Lineberger D W, Kessler J A, Waterbury J A, Byrnes V W, Massari F, Staszewski S, Emini E A
机构信息
Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486.
出版信息
J Virol. 1995 Apr;69(4):2637-9. doi: 10.1128/JVI.69.4.2637-2639.1995.
Abstract
A quantitative assessment of human immunodeficiency virus type 1 turnover in patient cell-free virion and infected-cell compartments under the dynamic conditions imposed by an effective antiviral therapy was performed. The turnover was rapid, and following a temporal lag, the extent of viral population replacement was eventually similar in both compartments. Each compartment therefore reflects considerable active virus replication.
摘要
在有效抗病毒治疗所施加的动态条件下，对患者游离病毒体和感染细胞区室中1型人类免疫缺陷病毒的周转进行了定量评估。周转速度很快，经过一段时间的延迟后，两个区室中病毒种群替换的程度最终相似。因此，每个区室都反映了相当活跃的病毒复制。
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