Shah D T, Glover D D, Larsen B
Department of Microbiology, Marshall University School of Medicine, Huntington, W.Va 25755.
Gynecol Obstet Invest. 1995;39(1):67-9. doi: 10.1159/000292381.
The virulence attributes of Candida albicans in cases of mucocutaneous disease have not been identified. Based on the recent finding that C. albicans is able to produce an immunosuppressive mycotoxin, gliotoxin, we analyzed vaginal samples of 3 women severely symptomatic for vaginal candidiasis and found that they contained significant levels of gliotoxin. Three control women who were not colonized with C. albicans showed no gliotoxin in vaginal samples. These findings raise the possibility that gliotoxin may play a role in the virulence of C. albicans.
白色念珠菌在黏膜皮肤疾病病例中的致病特性尚未明确。基于最近发现白色念珠菌能够产生一种免疫抑制性霉菌毒素——gliotoxin（胶霉毒素），我们分析了3名患有严重阴道念珠菌病症状的女性的阴道样本，发现其中含有大量的胶霉毒素。3名未被白色念珠菌定植的对照女性的阴道样本中未检测到胶霉毒素。这些发现增加了胶霉毒素可能在白色念珠菌致病性中发挥作用的可能性。
