霉菌毒素
Mycotoxins.
作者信息
Bennett J W, Klich M
机构信息
Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA.
出版信息
Clin Microbiol Rev. 2003 Jul;16(3):497-516. doi: 10.1128/CMR.16.3.497-516.2003.
Abstract
Mycotoxins are secondary metabolites produced by microfungi that are capable of causing disease and death in humans and other animals. Because of their pharmacological activity, some mycotoxins or mycotoxin derivatives have found use as antibiotics, growth promotants, and other kinds of drugs; still others have been implicated as chemical warfare agents. This review focuses on the most important ones associated with human and veterinary diseases, including aflatoxin, citrinin, ergot akaloids, fumonisins, ochratoxin A, patulin, trichothecenes, and zearalenone.
摘要
霉菌毒素是由微真菌产生的次生代谢产物，能够导致人类和其他动物患病甚至死亡。由于其药理活性，一些霉菌毒素或霉菌毒素衍生物已被用作抗生素、生长促进剂和其他类型的药物；还有一些被认为是化学战剂。本综述重点关注与人类和兽医疾病相关的最重要的霉菌毒素，包括黄曲霉毒素、桔霉素、麦角生物碱、伏马菌素、赭曲霉毒素A、展青霉素、单端孢霉烯族毒素和玉米赤霉烯酮。
相似文献
1
Mycotoxins.霉菌毒素
Clin Microbiol Rev. 2003 Jul;16(3):497-516. doi: 10.1128/CMR.16.3.497-516.2003.
2
Genotoxic effects of mycotoxins.霉菌毒素的遗传毒性作用。
Toxicon. 2020 Oct 15;185:104-113. doi: 10.1016/j.toxicon.2020.07.004. Epub 2020 Jul 10.
3
Mycotoxins: occurrence, toxicology, and exposure assessment.真菌毒素：发生、毒理学和暴露评估。
Food Chem Toxicol. 2013 Oct;60:218-37. doi: 10.1016/j.fct.2013.07.047. Epub 2013 Jul 29.
4
Mycotoxin: Its Impact on Gut Health and Microbiota.真菌毒素：对肠道健康和微生物组的影响。
Front Cell Infect Microbiol. 2018 Feb 26;8:60. doi: 10.3389/fcimb.2018.00060. eCollection 2018.
5
Mycotoxins and animal health.霉菌毒素与动物健康。
Adv Vet Sci Comp Med. 1981;25:185-243.
6
Some major mycotoxins and their mycotoxicoses--an overview.一些主要的霉菌毒素及其霉菌毒素中毒——概述
Int J Food Microbiol. 2007 Oct 20;119(1-2):3-10. doi: 10.1016/j.ijfoodmicro.2007.07.019. Epub 2007 Jul 31.
7
Current situation of mycotoxin contamination and co-occurrence in animal feed--focus on Europe.动物饲料中霉菌毒素污染及共存的现状--以欧洲为例。
Toxins (Basel). 2012 Oct;4(10):788-809. doi: 10.3390/toxins4100788. Epub 2012 Oct 1.
8
Mycotoxins, invisible danger of feedstuff with toxic effect on animals.真菌毒素，饲料中对动物具有毒性作用的隐形危险。
Toxicon. 2020 Jul 30;182:34-53. doi: 10.1016/j.toxicon.2020.04.101. Epub 2020 May 11.
9
Mycotoxins of possible importance in diseases of Canadian farm animals.在加拿大农场动物疾病中可能具有重要意义的霉菌毒素。
Can Vet J. 1975 May;16(5):125-41.
10
Fusarial toxins: secondary metabolites of Fusarium fungi.镰刀菌毒素：镰刀菌真菌的次生代谢物。
Rev Environ Contam Toxicol. 2014;228:101-20. doi: 10.1007/978-3-319-01619-1_5.
引用本文的文献
1
Molecular identification and mycotoxins analysis of some fungal isolates from postharvest decayed apple in Qena, Egypt.埃及基纳地区采后腐烂苹果中一些真菌分离株的分子鉴定及霉菌毒素分析
BMC Plant Biol. 2025 Sep 11;25(1):1200. doi: 10.1186/s12870-025-07205-2.
2
Drenched Pages: A Primer on Wet Books.湿透的书页：湿书入门指南。
Biology (Basel). 2025 Jul 22;14(8):911. doi: 10.3390/biology14080911.
3
Multiple Mycotoxin Contamination in Livestock Feed: Implications for Animal Health, Productivity, and Food Safety.家畜饲料中的多种霉菌毒素污染：对动物健康、生产力和食品安全的影响。
Toxins (Basel). 2025 Jul 25;17(8):365. doi: 10.3390/toxins17080365.
4
Aflatoxins contamination in spices marketed in selected areas of Tanzania and their Detection by Chromatographic Technique.坦桑尼亚某些地区销售的香料中的黄曲霉毒素污染及其色谱技术检测
Afr Health Sci. 2024 Jun;24(2):140-151. doi: 10.4314/ahs.v24i2.17.
5
Halophilic and halotolerant fungi across diverse climates: a comparative study of Polish and Italian soil ecosystems.不同气候条件下的嗜盐和耐盐真菌：波兰和意大利土壤生态系统的比较研究
Front Microbiol. 2025 Jul 28;16:1637496. doi: 10.3389/fmicb.2025.1637496. eCollection 2025.
6
Oral Exposure to Detoxifies Deoxynivalenol, Ochratoxin A, and Fumonisin B1 In Vitro and In Vivo.口服暴露在体外和体内均可对脱氧雪腐镰刀菌烯醇、赭曲霉毒素A和伏马菌素B1进行解毒。
Toxins (Basel). 2025 Jun 23;17(7):318. doi: 10.3390/toxins17070318.
7
A Ten-Year Trend Analysis of Mycotoxins in Croatian Maize (2014-2024).克罗地亚玉米中霉菌毒素的十年趋势分析（2014 - 2024年）
Foods. 2025 Jun 23;14(13):2209. doi: 10.3390/foods14132209.
8
Higher plasma AFB1 concentration is associated with increased risk of HPV 16 and HPV 18 detection and persistence among Ugandan women.较高的血浆黄曲霉毒素B1浓度与乌干达女性中检测到人乳头瘤病毒16型和18型以及病毒持续存在的风险增加有关。
Environ Health. 2025 Jul 7;24(1):45. doi: 10.1186/s12940-025-01197-0.
9
Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in .由GATA型调节因子NsdD介导的物种特异性基因调控网络重排 于……中
mBio. 2025 Jul 3:e0118125. doi: 10.1128/mbio.01181-25.
10
Research Progress and Management Strategies for the Common Mycotoxin Contamination of Traditional Chinese Medicines.中药常见霉菌毒素污染的研究进展与管理策略
J Fungi (Basel). 2025 May 27;11(6):411. doi: 10.3390/jof11060411.
本文引用的文献
1
Compositional Changes in Surface Mycoflora During Ripening of Naturally Fermented Sausages.自然发酵香肠成熟过程中表面真菌菌群的组成变化
J Food Prot. 1995 Apr;58(4):426-429. doi: 10.4315/0362-028X-58.4.426.
2
Toxins of Penicillium Species Used in Cheese Manufacture.用于奶酪制造的青霉菌毒素。
J Food Prot. 1981 Sep;44(9):702-710. doi: 10.4315/0362-028X-44.9.702.
3
Fumonisins, mycotoxins produced by fusarium species: biology, chemistry, and significance.伏马毒素，由镰刀菌属产生的霉菌毒素：生物学、化学及重要性
Annu Rev Phytopathol. 1993;31:233-52. doi: 10.1146/annurev.py.31.090193.001313.
4
Yellow Rain Experts Battle Over Corn Mold: An obscure toxin began killing chickens in Arizona 2 years ago; the experts fail to agree on what it is, but recent findings point to a compound similar to Yellow Rain toxins produced by a common corn mold.黄雨专家就玉米霉菌展开争论：一种不知名的毒素两年前开始在亚利桑那州致使鸡死亡；专家们对其是什么未能达成一致意见，但近期研究结果指向一种与常见玉米霉菌产生的黄雨毒素类似的化合物。
Science. 1983 Aug 5;221(4610):526-9. doi: 10.1126/science.221.4610.526.
5
Stachybotrys atra Growth and Toxin Production in Some Building Materials and Fodder under Different Relative Humidities.黑曲霉在不同相对湿度下在一些建筑材料和饲料中的生长和毒素产生。
Appl Environ Microbiol. 1994 Sep;60(9):3421-4. doi: 10.1128/aem.60.9.3421-3424.1994.
6
Genetics and physiology of aflatoxin biosynthesis.黄曲霉毒素生物合成的遗传学与生理学
Annu Rev Phytopathol. 1998;36:329-62. doi: 10.1146/annurev.phyto.36.1.329.
7
Biodefense. Peering into the shadows: Iraq's bioweapons program.生物防御。窥探阴影：伊拉克的生物武器计划。
Science. 2002 Aug 16;297(5584):1110-2. doi: 10.1126/science.297.5584.1110.
8
Occurrence of toxigenic Aspergillus versicolor isolates and sterigmatocystin in carpet dust from damp indoor environments.潮湿室内环境地毯灰尘中产毒杂色曲霉分离株及柄曲霉素的存在情况。
Appl Environ Microbiol. 2002 Aug;68(8):3886-90. doi: 10.1128/AEM.68.8.3886-3890.2002.
9
Nonfunctionality of Aspergillus sojae aflR in a strain of Aspergillus parasiticus with a disrupted aflR gene.在一株寄生曲霉中，米曲霉aflR基因缺失导致其功能丧失，该寄生曲霉的aflR基因已被破坏。
Appl Environ Microbiol. 2002 Aug;68(8):3737-43. doi: 10.1128/AEM.68.8.3737-3743.2002.
10
Binding rather than metabolism may explain the interaction of two food-Grade Lactobacillus strains with zearalenone and its derivative (')alpha-earalenol.结合而非代谢可能解释了两种食品级乳酸杆菌菌株与玉米赤霉烯酮及其衍生物α-玉米赤霉烯醇之间的相互作用。
Appl Environ Microbiol. 2002 Jul;68(7):3545-9. doi: 10.1128/AEM.68.7.3545-3549.2002.
Zotero 插件