Bennett J W, Klich M
Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA.
Clin Microbiol Rev. 2003 Jul;16(3):497-516. doi: 10.1128/CMR.16.3.497-516.2003.
Mycotoxins are secondary metabolites produced by microfungi that are capable of causing disease and death in humans and other animals. Because of their pharmacological activity, some mycotoxins or mycotoxin derivatives have found use as antibiotics, growth promotants, and other kinds of drugs; still others have been implicated as chemical warfare agents. This review focuses on the most important ones associated with human and veterinary diseases, including aflatoxin, citrinin, ergot akaloids, fumonisins, ochratoxin A, patulin, trichothecenes, and zearalenone.
霉菌毒素是由微真菌产生的次生代谢产物,能够导致人类和其他动物患病甚至死亡。由于其药理活性,一些霉菌毒素或霉菌毒素衍生物已被用作抗生素、生长促进剂和其他类型的药物;还有一些被认为是化学战剂。本综述重点关注与人类和兽医疾病相关的最重要的霉菌毒素,包括黄曲霉毒素、桔霉素、麦角生物碱、伏马菌素、赭曲霉毒素A、展青霉素、单端孢霉烯族毒素和玉米赤霉烯酮。