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In situ mycotoxin production by Candida albicans in women with vaginitis.白色念珠菌在阴道炎女性患者中产生原位霉菌毒素的情况。
Gynecol Obstet Invest. 1995;39(1):67-9. doi: 10.1159/000292381.
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Inhibition by sporidesmin of hepatocyte bile acid transport.孢霉菌素对肝细胞胆汁酸转运的抑制作用。
Biochem J. 1983 Apr 15;212(1):197-204. doi: 10.1042/bj2120197.
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Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader.使用自动酶免疫测定仪对培养的巨噬细胞产生超氧化物和过氧化氢进行测量的快速微量测定法。
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Influence of yeast mannan on human neutrophil functions: inhibition of release of myeloperoxidase related to carbohydrate-binding property of the enzyme.酵母甘露聚糖对人中性粒细胞功能的影响：与髓过氧化物酶碳水化合物结合特性相关的髓过氧化物酶释放抑制作用。
Infect Immun. 1981 May;32(2):731-8. doi: 10.1128/iai.32.2.731-738.1981.
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A sulfhydryl redox model of antibody-dependent phagocytosis.抗体依赖性吞噬作用的巯基氧化还原模型。
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Rapid killing of monocytes in vitro by Candida albicans yeast cells.白色念珠菌酵母细胞在体外对单核细胞的快速杀伤作用。
Infect Immun. 1986 Jan;51(1):307-13. doi: 10.1128/iai.51.1.307-313.1986.
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The effect of trichophytin and candidin on neutrophil chemotaxis.癣菌素与假丝菌素对中性粒细胞趋化性的作用。
Mycoses. 1988 Mar;31(3):137-42. doi: 10.1111/j.1439-0507.1988.tb03715.x.
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Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa.蛋白水解性念珠菌属在口腔黏膜实验性感染期间细胞外酸性蛋白酶的表达。
Infect Immun. 1988 Mar;56(3):626-31. doi: 10.1128/iai.56.3.626-631.1988.
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Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro.在烟曲霉培养物中鉴定出一种在体外具有抗吞噬和免疫调节活性的因子。
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Clinical isolates of yeast produce a gliotoxin-like substance.酵母的临床分离株会产生一种类胶质毒素物质。
Mycopathologia. 1991 Dec;116(3):203-8. doi: 10.1007/BF00436836.

Gliotoxin对人多形核中性粒细胞的影响。

Effect of gliotoxin on human polymorphonuclear neutrophils.

作者信息

Shah D T, Jackman S, Engle J, Larsen B

机构信息

Department of Pathology, Marshall University School of Medicine, Huntington, WV, USA.

出版信息

Infect Dis Obstet Gynecol. 1998;6(4):168-75. doi: 10.1002/(SICI)1098-0997(1998)6:4<168::AID-IDOG6>3.0.CO;2-Z.

DOI:10.1002/(SICI)1098-0997(1998)6:4<168::AID-IDOG6>3.0.CO;2-Z
PMID:9812249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1784797/
Abstract

OBJECTIVES

Candida albicans is known to produce gliotoxin, which has several prominent biological effects, including immunosuppression. Interference with host defenses may arise from the effects of this toxin on leukocyte structure and function.

METHODS

Flow cytometric analysis revealed that polymorphonuclear leukocytes (PMN) were more sensitive to gliotoxin than were mononuclear cells. Structural and various functional aspects of PMN exposed to gliotoxin were studied.

RESULTS

Gliotoxin at (1 microgram/mL) did not affect the viability but did diminish PMN chemotaxis and reduced their ability to ingest particles. Other functional aberrations included decreased nitroblue tetrazolium dye reduction, decreased superoxide production, and release of lactoferrin suggesting by degranulation. Gliotoxin also affected the ability of PMN to kill Escherichia coli.

CONCLUSIONS

This study suggests a previously unrecognized potential virulence factor of C. albicans that could contribute to persistence of yeast colonization or recurrence of symptomatic infection through diminished host resistance.

摘要

目的

已知白色念珠菌可产生胶质毒素，该毒素具有多种显著的生物学效应，包括免疫抑制。这种毒素对白细胞结构和功能的影响可能会干扰宿主防御。

方法

流式细胞术分析显示，多形核白细胞（PMN）对胶质毒素比单核细胞更敏感。研究了暴露于胶质毒素的PMN的结构和各种功能方面。

结果

1微克/毫升的胶质毒素不影响细胞活力，但会降低PMN的趋化性并降低其摄取颗粒的能力。其他功能异常包括硝基蓝四氮唑染料还原减少、超氧化物产生减少以及通过脱颗粒释放乳铁蛋白。胶质毒素还影响PMN杀死大肠杆菌的能力。

结论

本研究提示白色念珠菌存在一种先前未被认识的潜在毒力因子，它可能通过降低宿主抵抗力导致酵母菌定植持续存在或症状性感染复发。