Erkel G, Lorenzen K, Anke T, Velten R, Gimenez A, Steglich W
Lehrbereich Biotechnologie der Universität, Bundesrepublik, Deutschland.
Z Naturforsch C J Biosci. 1995 Jan-Feb;50(1-2):1-9. doi: 10.1515/znc-1995-1-202.
In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 microM) and moloney murine leukemia virus (Ki 40 microM) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.
为了寻找RNA定向DNA聚合酶的新型抑制剂，从塔斯马尼亚库恩酵母属物种的发酵产物中分离出了库恩霉素A（1）。通过光谱方法阐明了其结构。库恩霉素A（1）是禽成髓细胞瘤病毒逆转录酶（Ki 200 microM）和莫洛尼鼠白血病病毒逆转录酶（Ki 40 microM）的非竞争性抑制剂。第二种化合物库恩霉素B（2）是不同诱导剂刺激血小板聚集的强抑制剂。此外，这两种化合物都具有细胞毒性和抗菌活性。
