老年大鼠脑区一氧化氮合酶与自由基生成：与个体行为的相关性

NO synthase and free radical generation in brain regions of old rats: correlations with individual behaviour.

作者信息

Gulyaeva N V, Onufriev M V

机构信息

Laboratory of Functional Biochemistry of the Nervous System, Russian Academy of Sciences, Moscow.

出版信息

Neuroreport. 1994 Dec 30;6(1):94-6. doi: 10.1097/00001756-199412300-00025.

DOI:10.1097/00001756-199412300-00025

PMID:7535579

Abstract

We have investigated the activity of NO synthase (NOS) and generation of free radicals (FRG) in selected brain regions of old male Wistar rats. Using the emotional resonance test, two groups of rats were selected for the experiment: passive, preferring dark space and active, preferring light space. Highest NOS activity and FRG were seen in cerebellum. As a rule, NOS activity was lower and FRG higher in the respective brain regions of active rats than in passive rats. Positive linear inter-regional cross-correlations of NOS activity as well as of FRG were found. When all rats were assessed as one group, negative correlations between NOS and FRG in cerebral cortex were revealed.

摘要

我们研究了老年雄性Wistar大鼠特定脑区中一氧化氮合酶（NOS）的活性和自由基（FRG）的生成。通过情绪共鸣测试，选择两组大鼠进行实验：被动组，偏好黑暗空间；主动组，偏好明亮空间。小脑的NOS活性和FRG最高。通常，主动组大鼠相应脑区的NOS活性低于被动组，而FRG则高于被动组。发现NOS活性和FRG在区域间呈正线性交叉相关。当将所有大鼠作为一组进行评估时，发现大脑皮层中NOS和FRG之间呈负相关。