氨氯吡咪与大鼠腮腺毒蕈碱型和α-肾上腺素能受体的相互作用。

Interaction of amiloride with rat parotid muscarinic and alpha-adrenergic receptors.

Dehaye J P, Verhasselt V

Department of Biochemistry, Université libre de Bruxelles, Belgium.

Gen Pharmacol. 1995 Jan;26(1):155-9. doi: 10.1016/0306-3623(94)00153-e.

Abstract

In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine. 2. Amiloride competitively inhibited the binding of [3H]N-methylscopolamine and [3H] is thus a competitive antagonist of muscarinic and norepinephrine alpha-adrenergic receptors. 3. Amiloride did not affect the response to substance P with respect to secretion or ion movements. 4. Thus the Na+/H+ antiporter is not involved in the short-term regulation of amylase secretion and calcium and potassium movements in rat parotid gland function.

摘要

在大鼠腮腺腺泡中，氨氯地平抑制了淀粉酶的分泌以及对氨甲酰胆碱和去甲肾上腺素的钙和铷外流。2. 氨氯地平竞争性抑制[3H]N-甲基东莨菪碱的结合，因此是毒蕈碱和去甲肾上腺素α-肾上腺素能受体的竞争性拮抗剂。3. 氨氯地平在分泌或离子运动方面不影响对P物质的反应。4. 因此，Na+/H+反向转运体不参与大鼠腮腺功能中淀粉酶分泌以及钙和钾运动的短期调节。