Skretting A, Aas M, Normann E, Sødal G, Lindegaard M W
Eur J Nucl Med. 1978;3(1):5-9. doi: 10.1007/BF00253470.
Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.
本文介绍了应用三重放射性核素减影研究对甲状旁腺肿大进行术前定位的临床结果。静脉注射131I-甲苯胺蓝后记录闪烁相机图像。在分别注射99mTcO4-和113mIn后获得额外图像后，使用迭代计算机算法确定甲状腺和血液中活性对该图像的贡献，该算法还提供均匀背景的估计值。减去这些贡献后得到的图像可解释为131I-甲苯胺蓝在甲状旁腺中的选择性积聚图像。21例中有17例正确定位了一个或多个肿大的腺体，但有4例仅出现假阳性。在10例中，正确定位的腺体重量为900毫克或以下。
