Candenas M, Villa R, Fernandez Collar R, Moina M J, Pintado S, Garcia Saez F, Alvarez F V
Department of Clinical Analysis, Hospital San Agustín, Avilés-Asturias, Spain.
Acta Obstet Gynecol Scand. 1995 Apr;74(4):266-9. doi: 10.3109/00016349509024447.
Maternal serum alphafetoprotein (MSAFP) screening has been set up in Asturias, in the north of Spain, in 1987 in order to make possible the prenatal diagnosis of neural tube defects (NTD) to overall pregnancy population. This large study shows the high sensitivity and specificity of MSAFP screening when it is done with absolute control of all variables such as gestational age, pregnant woman's weight, diabetes, etc. On the other hand, this study also shows a poor sensitivity second level ultrasound for the early diagnosis of NTD in the presence of spina bifidas with no bulge. We have also observed that the incidence of NTD in Asturias remained constant in the last six years, around 1.5-1.6 per 1000 pregnancies. However, due to MSAFP screening, there has been a decline in the prevalence of children born with these defects. We conclude that MSAFP screening is the best tool to identify and reduce NTD in our Region (Spain).
1987年，西班牙北部的阿斯图里亚斯地区开展了母血清甲胎蛋白（MSAFP）筛查，以便对全体孕妇进行神经管缺陷（NTD）的产前诊断。这项大型研究表明，在对所有变量（如孕周、孕妇体重、糖尿病等）进行绝对控制的情况下进行MSAFP筛查，具有很高的敏感性和特异性。另一方面，这项研究还表明，对于无隆起的脊柱裂导致的NTD早期诊断，二级超声检查的敏感性较差。我们还观察到，阿斯图里亚斯地区NTD的发病率在过去六年中保持稳定，每1000例妊娠约为1.5 - 1.6例。然而，由于MSAFP筛查，患有这些缺陷的儿童患病率有所下降。我们得出结论，MSAFP筛查是我们地区（西班牙）识别和减少NTD的最佳工具。
