Rodgers K
Livingstone Research Laboratory, Los Angeles, California, USA.
Hum Exp Toxicol. 1995 Jan;14(1):111-3. doi: 10.1177/096032719501400126.
Many pesticides that are widely used and have great potential for occupational and public exposure have received only a cursory examination with regards to their immunotoxic potential. Many of the studies that are available were done during the early period of immunotoxicology and many reports do not state whether or not any other toxic signs were observed and the dose-response relationships were not generally examined. Most studies were done in multiple species, through various routes of administration and using a variety of assays of immune function and do not allow a comparison. For the compounds extensively studied, the site of action has been determined at the cellular and perhaps the biochemical level, but the molecular site of action has not been determined. The approach to evaluate the mechanism of action will vary from compound to compound.
许多广泛使用且具有很大职业和公众接触可能性的农药，在其免疫毒性潜力方面仅得到了粗略的研究。现有的许多研究是在免疫毒理学早期进行的，许多报告未说明是否观察到任何其他毒性迹象，并且通常未研究剂量反应关系。大多数研究是在多个物种中进行的，通过各种给药途径并使用多种免疫功能检测方法，无法进行比较。对于经过广泛研究的化合物，其作用位点已在细胞水平甚至可能在生化水平上确定，但分子作用位点尚未确定。评估作用机制的方法因化合物而异。
