Popović M, Daković-Svajcer K, Nerudova J, Trivić S
Arh Hig Rada Toksikol. 1989 Sep;40(3):277-83.
The effects of various pesticides (lindane, binapacrile and parathion) on the content of cytochrome P450 and glutathione, and on the activity of lipoperoxidase, xanthine oxidase and transaminases (SGOT and SPGT) were examined. Other parameters, such as the relative liver mass and hepatocyte viability were also estimated. All the studied parameters in the liver homogenate and in hepatocytes were changed by binapacrile, whereas in blood only the glutathione level was altered. Lindane produced an effect on all the parameters. In hepatocytes it did not affect only the lipoperoxidase activity. In the blood it changed only the level of glutathione content. Parathion, in the liver homogenate, changed all of the parameters examined, whereas in hepatocytes only lipoperoxidase activity remained unchanged. In the blood parathion caused a slight increase in the sulphhaemoglobin level and decreased the glutathione content.
研究了各种农药（林丹、螨腈、对硫磷）对细胞色素P450和谷胱甘肽含量以及脂过氧化酶、黄嘌呤氧化酶和转氨酶（谷草转氨酶和谷丙转氨酶）活性的影响。还评估了其他参数，如相对肝脏质量和肝细胞活力。螨腈使肝脏匀浆和肝细胞中的所有研究参数发生变化，而在血液中仅谷胱甘肽水平改变。林丹对所有参数都有影响。在肝细胞中，它仅不影响脂过氧化酶活性。在血液中，它仅改变谷胱甘肽含量水平。在肝脏匀浆中，对硫磷改变了所有检测参数，而在肝细胞中只有脂过氧化酶活性保持不变。在血液中，对硫磷导致硫血红蛋白水平略有升高并降低了谷胱甘肽含量。
