Olesen J, Thomsen L L, Iversen H
Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark.
Trends Pharmacol Sci. 1994 May;15(5):149-53. doi: 10.1016/0165-6147(94)90075-2.
Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics. At relatively high doses of glyceryl trinitrate, migraine sufferers develop stronger and more migraine-like headaches and more pronounced cerebral arterial dilatation than controls. After the infusion of glyceryl trinitrate, non-migraineurs remain headache-free while migraineurs develop a migraine-like attack. In this review, Jes Olesen, Lars Thomsen and Helle Iversen suggest that migraine may be caused by increased amounts and/or affinity of an enzyme in the NO-triggered cascade of reactions. NO may also be involved in the pathogenesis of other vascular headaches.
一氧化氮（NO）可能在偏头痛及其他血管性头痛中起关键作用，因为硝酸甘油（一种NO供体）和组胺（可能激活内皮细胞生成NO）都会引发具有多种偏头痛特征的搏动性剂量依赖性头痛。在相对高剂量的硝酸甘油作用下，偏头痛患者比对照组会出现更强且更类似偏头痛的头痛，以及更明显的脑动脉扩张。输注硝酸甘油后，非偏头痛患者不会出现头痛，而偏头痛患者则会发作类似偏头痛的症状。在这篇综述中，杰斯·奥莱森、拉尔斯·汤姆森和赫勒·艾弗森认为，偏头痛可能是由NO引发的反应级联中一种酶的量增加和/或亲和力增加所致。NO也可能参与其他血管性头痛的发病机制。
