Olesen J, Thomsen L L, Lassen L H, Olesen I J
Department of Neurology, Glostrup Hospital, Copenhagen, Denmark.
Cephalalgia. 1995 Apr;15(2):94-100. doi: 10.1046/j.1468-2982.1995.015002094.x.
The molecular mechanisms of migraine pain remain to be determined. Our studies of glyceryl trinitrate (GTN)-induced and histamine-induced headaches have led us to propose that nitric oxide (NO) may be the causative molecule in migraine pain. We also propose that substances capable of inducing experimental vascular headache do so with NO as the common mediator. Finally, we suggest that drugs with antimigraine activity inhibit NO and the cascade of intracellular reactions triggered by NO. We believe these observations provide new insight into the mechanisms of vascular headache. The importance of NO as a potential initiator of the migraine attack indicates new directions for the pharmacological treatment of migraine and other vascular headaches.
偏头痛疼痛的分子机制仍有待确定。我们对硝酸甘油（GTN）诱发和组胺诱发头痛的研究使我们提出，一氧化氮（NO）可能是偏头痛疼痛的致病分子。我们还提出，能够诱发实验性血管性头痛的物质是以NO作为共同介质来实现的。最后，我们认为具有抗偏头痛活性的药物可抑制NO以及由NO触发的细胞内反应级联。我们相信这些观察结果为血管性头痛的机制提供了新的见解。NO作为偏头痛发作潜在启动因子的重要性为偏头痛和其他血管性头痛的药物治疗指明了新方向。
