Mehlman P T, Higley J D, Faucher I, Lilly A A, Taub D M, Vickers J, Suomi S J, Linnoila M
Laboratory Animal Breeders and Services, Inc., Yemassee, SC 29945, USA.
Am J Psychiatry. 1995 Jun;152(6):907-13. doi: 10.1176/ajp.152.6.907.
The purpose of this study was to examine the relationship between behavior and serotonin in nonhuman primates.
During a routine capture and medical examination, 26 adolescent male rhesus macaques (Macaca mulatta) were selected as subjects from a free-ranging population of 4,500 rhesus monkeys inhabiting a 475-acre sea island. Blood samples (N = 23) and CSF samples (N = 22) were obtained, and each subject was fitted with a radio transmitter collar for rapid location. The subjects were released into their social groups, and quantitative behavioral observations were made over a 3-month period.
CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration was positively correlated with three measures of sociality: 1) total time spent grooming others, 2) total time spent in close proximity to other group members, and 3) mean number of neighbors within a 5-m radius. In addition, CSF 5-HIAA concentration was positively correlated with age at emigration from the natal group (in months).
In adolescent male rhesus macaques living in naturalistic settings, CSF 5-HIAA concentration is positively correlated with affiliative sociality. Rhesus males with low CSF 5-HIAA concentrations exhibit less social competence and emigrate from their social groups at a younger age than do males with higher concentrations of CSF 5-HIAA.
本研究旨在探讨非人灵长类动物的行为与血清素之间的关系。
在一次常规捕获和医学检查期间，从居住在一个475英亩海岛的4500只恒河猴的自由放养群体中挑选了26只青春期雄性恒河猴（猕猴）作为研究对象。采集了血样（n = 23）和脑脊液样本（n = 22），并为每只研究对象佩戴了一个无线电发射器项圈以便快速定位。研究对象被放归到它们的社会群体中，并在3个月的时间内进行了定量行为观察。
脑脊液5-羟吲哚乙酸（5-HIAA）浓度与三种社交性指标呈正相关：1）用于为其他个体梳理毛发的总时间；2）与其他群体成员近距离相处的总时间；3）半径5米范围内的平均邻居数量。此外，脑脊液5-HIAA浓度与从出生群体迁出时的年龄（以月为单位）呈正相关。
在自然环境中生活的青春期雄性恒河猴中，脑脊液5-HIAA浓度与亲和性社交呈正相关。脑脊液5-HIAA浓度低的恒河猴雄性比浓度高的雄性表现出更低的社交能力，并且在更年轻的时候就从它们的社会群体中迁出。
