Yoshikawa M, Ueda T, Muraoka O, Aoyama H, Matsuda H, Shimoda H, Yamahara J, Murakami N
Kyoto Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1995 Mar;43(3):532-4. doi: 10.1248/cpb.43.532.
Two bioactive novel triterpene glycosides named hovenidulciosides A1 and A2 have been isolated from a Chinese natural medicine, Hoveniae Semen Seu Fructus, the seeds and fruit of Hovenia dulcis Thunb. (Rhamnaceae). The absolute stereostructures of hovenidulciosides A1 and A2 with a migrated 16,17-seco-dammarane skeleton have been determined on the basis of chemical and physicochemical evidence which included the X-ray crystallographic analysis of the p-bromobenzoate of their common aglycone, hovenidulcigenin A. Hovenidulciosides A1 and A2 exhibited inhibitory activity on the histamine release from rat mast cells induced by compound 48/80 or calcium ionophore A-23187.
从中国天然药物枳椇子（鼠李科植物北枳椇Hovenia dulcis Thunb. 的种子和果实）中分离出了两种具有生物活性的新型三萜糖苷，分别命名为枳椇苷A1和A2。基于化学和物理化学证据，包括对其共同苷元枳椇苷元A的对溴苯甲酸酯进行X射线晶体学分析，确定了具有16,17-裂环达玛烷骨架的枳椇苷A1和A2的绝对立体结构。枳椇苷A1和A2对化合物48/80或钙离子载体A-23187诱导的大鼠肥大细胞组胺释放具有抑制活性。
