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生物活性皂苷和糖苷。十、酸枣仁（酸枣，鼠李科枣属植物酸枣的种子）的成分（1）：酸枣仁皂苷A1、C及乙酰酸枣仁皂苷B的结构与组胺释放抑制作用

Bioactive saponins and glycosides. X. On the constituents of zizyphi spinosi semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu (1): structures and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B.

作者信息

Yoshikawa M, Murakami T, Ikebata A, Wakao S, Murakami N, Matsuda H, Yamahara J

机构信息

Kyoto Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1997 Jul;45(7):1186-92. doi: 10.1248/cpb.45.1186.

DOI:10.1248/cpb.45.1186
PMID:9246753
Abstract

New dammarane-type triterpene oligoglycosides, jujubosides A1 and C and acetyljujuboside B1 were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba MILL. var. spinosa Hu, together-with three known saponins. The structures of jujubosides A1 and C and acetyljujuboside B were determined on the basis of chemical and physicochemical evidence. Jujubosides A1 and C and acetyljujuboside B were found to inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody-reaction.

摘要

从酸枣（鼠李科枣属植物酸枣的种子）中分离出了新的达玛烷型三萜寡糖苷——酸枣仁皂苷A1、C和乙酰酸枣仁皂苷B1，以及三种已知的皂苷。基于化学和物理化学证据确定了酸枣仁皂苷A1、C和乙酰酸枣仁皂苷B的结构。发现酸枣仁皂苷A1、C和乙酰酸枣仁皂苷B可抑制抗原抗体反应诱导的大鼠腹腔渗出细胞释放组胺。

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