De Caterina R, Cybulsky M A, Clinton S K, Gimbrone M A, Libby P
Department of Medicine, Brigham and Women's Hospital-Harvard Medical School, Boston, MA 02115, USA.
Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar;52(2-3):191-5. doi: 10.1016/0952-3278(95)90021-7.
Although dietary fatty acids can modulate atherogenesis and inflammation, the mechanisms by which this occurs are poorly understood. Induction in endothelial cells of adhesion molecules for circulating leukocytes and of inflammatory mediators by cytokines likely contributes to early phases of atherogenesis and inflammation. We report here that incorporation into cellular lipids of one specific fatty acid of the omega-3 family, docosahexaenoic acid (DHA), decreases cytokine-induced expression of endothelial leukocyte adhesion molecules, secretion of inflammatory mediators, and leukocyte adhesion to endothelial cells. These properties of DHA may contribute to antiatherogenic and antiinflammatory effects of omega-3 fatty acids.
尽管膳食脂肪酸可以调节动脉粥样硬化的形成和炎症反应，但其发生机制却知之甚少。细胞因子诱导循环白细胞的黏附分子在内皮细胞中的表达以及炎症介质的产生，可能在动脉粥样硬化形成和炎症反应的早期阶段发挥作用。我们在此报告，ω-3家族的一种特定脂肪酸二十二碳六烯酸（DHA）掺入细胞脂质中，可降低细胞因子诱导的内皮白细胞黏附分子的表达、炎症介质的分泌以及白细胞与内皮细胞的黏附。DHA的这些特性可能有助于ω-3脂肪酸的抗动脉粥样硬化和抗炎作用。
