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成人慢性肺病患者支气管黏膜中神经内分泌成分的变化

Changes in neuroendocrine elements in bronchial mucosa in chronic lung disease in adults.

作者信息

Pilmane M, Luts A, Sundler F

机构信息

Department of Histology and Embryology, Medical Academy of Latvia.

出版信息

Thorax. 1995 May;50(5):551-4. doi: 10.1136/thx.50.5.551.

DOI:10.1136/thx.50.5.551
PMID:7541167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1021228/
Abstract

BACKGROUND

It is not clear whether there is any association between metaplasia of the bronchial epithelium and changes in the distribution of neuroendocrine cells. This study examined, by immunohistological techniques, the distribution of neuroendocrine cells and juxtamucoscal nerve fibres in bronchial biopsies showing metaplastic changes.

METHODS

Bronchial biopsies from 12 subjects with epithelial metaplasia associated with bronchiectasis and diffuse pulmonary fibrosis were examined by conventional light microscopy and immunohistological techniques for protein gene product 9.5 (PGP), chromogranin A and B (CAB), serotonin, vasoactive intestinal peptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP), calcitonin (CT), and gastrin releasing peptide (GRP).

RESULTS

Regions of non-metaplastic epithelium contained numerous PGP and serotonin immunoreactive cells. Sub-populations of these cells displayed CAB, CGRP, CT, and GRP immunoreactivity. Metaplastic epithelium contained only a few weakly stained PGP, serotonin, CAB, GRP, CT and CGRP immunoreactive cells in six cases. Metaplastic epithelium was characterised by a high number of CAB-containing cells in six cases and in these biopsies prominent PGP-containing nerve bundles were seen in the subepithelial layer beneath the metaplastic epithelium.

CONCLUSIONS

The distribution patterns of neuroendocrine cells and neuronal elements vary between areas of normal and metaplastic epithelium and within areas of metaplastic epithelium. Neuronal hyperplasia was associated with an increase in the number of CAB-containing cells within the metaplastic epithelium.

摘要

背景

尚不清楚支气管上皮化生与神经内分泌细胞分布变化之间是否存在关联。本研究采用免疫组织学技术，检查了显示化生改变的支气管活检组织中神经内分泌细胞和黏膜下神经纤维的分布情况。

方法

对12例患有与支气管扩张和弥漫性肺纤维化相关的上皮化生的受试者的支气管活检组织进行常规光学显微镜检查和免疫组织学技术检测，以检测蛋白质基因产物9.5（PGP）、嗜铬粒蛋白A和B（CAB）、5-羟色胺、血管活性肠肽（VIP）、P物质（SP）、降钙素基因相关肽（CGRP）、降钙素（CT）和胃泌素释放肽（GRP）。

结果

未化生上皮区域含有大量PGP和5-羟色胺免疫反应性细胞。这些细胞的亚群显示出CAB、CGRP、CT和GRP免疫反应性。在6例病例中，化生上皮仅含有少量弱染色的PGP、5-羟色胺、CAB、GRP、CT和CGRP免疫反应性细胞。在6例病例中，化生上皮的特征是含有大量含CAB的细胞，并且在这些活检组织中，在化生上皮下方的上皮下层可见突出的含PGP的神经束。

结论

神经内分泌细胞和神经元成分的分布模式在正常上皮和化生上皮区域之间以及化生上皮区域内有所不同。神经元增生与化生上皮内含CAB细胞数量的增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/4f70af493818/thorax00310-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/a7f3180d9aa7/thorax00310-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/ede48cdd6716/thorax00310-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/4f70af493818/thorax00310-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/a7f3180d9aa7/thorax00310-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/ede48cdd6716/thorax00310-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/1021228/4f70af493818/thorax00310-0087-a.jpg

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