Ishihara Y, Maruyama S, Yagita A, Atomi Y, Tachikawa I, Takenoshita S, Nagamachi Y, Shibusawa M, Kusano M, Miura S, Kodaira S, Nakajima A, Koyanagi Y, Kimura K, Anazawa S, Sakurai K, Iwamoto M, Itsubo K, Kameoka S, Hamano K, Kajiwara T, Sugita M, Ugajin W, Shibata M, Kurosu Y
Department of Hygiene and Public Health, Tokyo Women's Medical College, Japan.
Gan To Kagaku Ryoho. 1996 Feb;23(3):333-41.
We developed a new questionnaire in the surgical area based on a core quality of life (QOL) questionnaire for patients with gastrointestinal cancer. In this study, we investigated the validity and reliability of a QOL questionnaire (Tokyo Yamabuki Forum Version) for patients with colorectal cancer. The questionnaire was composed of 17 items including 5 scales (basic sensory scale, psychological scale, physiological scale, defection-related scale and active scale) and a face scale as an global scale. The time needed to answer questionnaires was expected to be around 7 minutes and the questionnaires should basically be answered by the patients themselves everyday in the hospital. The study was performed in 10 hospitals in the Tokyo area, and 394 samples collected from 21 patients with rectal and colonic cancers were analyzed. A number of respondents failed to answer the question "Do you feel your foods tasty?", so we judged this item inappropriate and deleted it from the analysis. Fifteen items, including 5 scales showed satisfactory internal consistency and construct validity in correlation and factor analyses. Performance status showed a low correlation between each item, each scale and the global scale, while SDS and STAI showed an inordinately negative correlation with the fundamental and physical scales. Especially, SDS revealed an extremely close correlation with the active scale, and STAI showed an excessive correlation with the psychological scale. In the time course of QOL under chemotherapy, reductions (aggravations) were observed in both the total score of 15 items and global scale within one week postoperatively, but after that recovered to preoperative levels at 2 weeks postoperatively. A tendency to QOL improvement was observed 2 weeks after starting chemotherapy or chemoimmunotherapy. QOL of 13 patients was measured over 3 months, and the longest term was 8 months. The results suggested that this QOL questionnaire has sufficient reliability and validity to be usable for patients with colorectal cancer in the surgical area and that this model is applicable for long-term QOL surveys and frequent measurement.
我们基于一份针对胃肠道癌症患者的核心生活质量（QOL）问卷，开发了一份外科领域的新问卷。在本研究中，我们调查了一份针对结直肠癌患者的生活质量问卷（东京山吹论坛版）的有效性和可靠性。该问卷由17个项目组成，包括5个量表（基本感觉量表、心理量表、生理量表、排便相关量表和活动量表）以及一个作为整体量表的面容量表。预计回答问卷所需时间约为7分钟，且问卷原则上应由患者本人在医院每天自行填写。该研究在东京地区的10家医院进行，对从21例直肠癌和结肠癌患者中收集的394份样本进行了分析。许多受访者未回答“你觉得食物美味吗？”这个问题，因此我们判定该项目不合适，并将其从分析中删除。包括5个量表在内的15个项目在相关性和因子分析中显示出令人满意的内部一致性和结构效度。表现状态在各项目、各量表与整体量表之间显示出较低的相关性，而抑郁自评量表（SDS）和状态特质焦虑问卷（STAI）与基本量表和身体量表显示出过度的负相关。特别是，SDS与活动量表显示出极其密切的相关性，STAI与心理量表显示出过高的相关性。在化疗期间的生活质量时间进程中，术后一周内15个项目的总分和整体量表均出现下降（恶化），但之后在术后2周恢复到术前水平。在开始化疗或化疗免疫治疗2周后观察到生活质量有改善的趋势。对13例患者的生活质量进行了3个月的测量，最长为期8个月。结果表明，这份生活质量问卷具有足够的可靠性和有效性，可用于外科领域的结直肠癌患者，且该模型适用于长期生活质量调查和频繁测量。
