Antipa C, Spânache A, Constantinescu M, Baltă N, Cernescu C
Stephan S. Nicolau Institute of Virology, Bucharest, Romania.
Rev Roum Virol. 1994 Jul-Dec;45(3-4):115-21.
Chronic viral hepatitis must be distinguished from other chronic liver disorders. The clinical picture associated with typical biochemical findings provides no definite information about the causative agent. An important factor, both for the patient and for the individuals in contact with him, is the evaluation of his infectivity. From 172 chronic hepatitis disorders the serological diagnosis confirmed the viral etiology in 120 patients (69.7%). HBsAg was present in 33.7% (with HBeAg in 5%), anti-HCV antibodies 22.6% and markers for both viruses in 13.4% of cases. The HCV etiology was more frequently found in chronic hepatitis (44.9%) in liver cirrhosis (50.7%). The smaller number of patients displaying simultaneously anti-HBs and anti HCV antibodies did not confirm the recent suggestions that HCV would be the most important hepatotropic virus which enhances HBsAg clearance in chronic hepatitis.
慢性病毒性肝炎必须与其他慢性肝脏疾病相鉴别。典型生化检查结果所关联的临床表现无法提供有关病原体的确切信息。对于患者及其接触者而言，一个重要因素是对其传染性的评估。在172例慢性肝炎疾病中，血清学诊断证实120例患者（69.7%）的病因是病毒感染。33.7%的患者存在乙肝表面抗原（其中5%伴有乙肝e抗原），22.6%的患者存在抗丙型肝炎病毒抗体，13.4%的病例同时存在两种病毒的标志物。丙型肝炎病毒病因在慢性肝炎患者中更为常见（44.9%），在肝硬化患者中也较为常见（50.7%）。同时显示抗乙肝表面抗体和抗丙型肝炎病毒抗体的患者数量较少，这并不支持最近关于丙型肝炎病毒是增强慢性肝炎中乙肝表面抗原清除的最重要嗜肝病毒的观点。
