Filteau S M, Morris S S, Raynes J G, Arthur P, Ross D A, Kirkwood B R, Tomkins A M, Gyapong J O
International Child Health, Institute of Child Health, London, UK.
Am J Clin Nutr. 1995 Aug;62(2):434-8. doi: 10.1093/ajcn/62.2.434.
The association of vitamin A supplementation with concentrations of positive acute-phase proteins in the serum was investigated in the Child Health Study of the Ghana Vitamin A Supplementation Trials, a randomized, controlled trial of the effect of vitamin A on morbidity in children aged < 5 y. Mean serum concentrations of alpha 1-acid glycoprotein, serum amyloid A, and C-reactive protein did not differ overall between the vitamin A-supplemented and placebo-treated groups. Treatment groups were then subdivided according to what symptoms children had experienced in the week before blood sampling. Acute-phase-protein responses to fever and cough were not affected by vitamin A supplementation. There was a tendency for vitamin A-supplemented children, but not placebo children, to have elevated acute-phase proteins in association with reported vomiting or severe diarrhea. The failure of unsupplemented children to mount an acute-phase response may have contributed to their increased morbidity from gastrointestinal symptoms.
在加纳维生素A补充试验儿童健康研究中，对血清中维生素A补充与阳性急性期蛋白浓度之间的关联进行了调查。该研究是一项关于维生素A对5岁以下儿童发病率影响的随机对照试验。补充维生素A组和安慰剂治疗组之间，α1-酸性糖蛋白、血清淀粉样蛋白A和C反应蛋白的平均血清浓度总体上没有差异。然后根据儿童在采血前一周所经历的症状对治疗组进行细分。维生素A补充对发热和咳嗽的急性期蛋白反应没有影响。补充维生素A的儿童，但不是服用安慰剂的儿童，有与报告的呕吐或严重腹泻相关的急性期蛋白升高的趋势。未补充维生素A的儿童未能产生急性期反应，这可能导致了他们胃肠道症状发病率的增加。
