Binka F N, Ross D A, Morris S S, Kirkwood B R, Arthur P, Dollimore N, Gyapong J O, Smith P G
Ministry of Health, Ghana.
Am J Clin Nutr. 1995 Apr;61(4):853-9. doi: 10.1093/ajcn/61.4.853.
Two companion, randomized, placebo-controlled trials of prophylactic vitamin A supplementation provided the opportunity to assess the impact of supplementation on malaria parasitemia, morbidity, and mortality in young children in northern Ghana. In the mortality study, 21,906 children were visited every 4 mo over 2 y, and in the morbidity study 1455 children were visited weekly for 1 y. There was no difference between children supplemented with vitamin A and those given placebo in malaria mortality rates (rate ratio = 1.03; 95% CI 0.74, 1.43) or fever incidence based on reported symptoms. Malaria parasitemia rates, parasite densities in children with a positive blood smear, and rates of probable malaria illness also did not differ between treatment groups. There was no correlation between serum retinol at the beginning of the trial and subsequent malaria parasitemia in children who received placebo (r = 0.01). It is concluded that vitamin A supplementation had no impact on malaria in this population.
两项配套的随机、安慰剂对照预防性补充维生素A试验，为评估补充维生素A对加纳北部幼儿疟疾寄生虫血症、发病率和死亡率的影响提供了机会。在死亡率研究中，21906名儿童在两年内每4个月接受一次访视，在发病率研究中，1455名儿童每周接受一次访视，为期1年。补充维生素A的儿童与服用安慰剂的儿童在疟疾死亡率（率比=1.03；95%CI 0.74，1.43）或根据报告症状得出的发热发病率方面没有差异。治疗组之间的疟疾寄生虫血症率、血涂片阳性儿童的寄生虫密度以及可能的疟疾疾病发病率也没有差异。在接受安慰剂的儿童中，试验开始时的血清视黄醇与随后的疟疾寄生虫血症之间没有相关性（r=0.01）。得出的结论是，补充维生素A对该人群的疟疾没有影响。
