Invitti C, Brunani A, Pasqualinotto L, Dubini A, Bendinelli P, Maroni P, Cavagnini F
Department of Endocrinology, University of Milan, Scientific Institute San Luca Hospital, Italy.
Int J Obes Relat Metab Disord. 1995 May;19(5):347-9.
Galanin is believed to play a role in the control of eating behavior. No information is available on its concentrations in the biological fluids in human obesity, and this study aimed to clarify this.
We measured plasma galanin and serum insulin levels in 30 obese, 35 normal weight and 11 anorectic women.
Mean galanin values were quite similar in obese and control subjects (76.8 +/- 3.20 vs 76.1 +/- 2.33 pg/ml) and only slightly reduced in anorectic patients (67.9 +/- 2.30 pg/ml). Insulin levels were significantly increased and decreased in obese and anorectic patients, respectively, compared to controls. Insulin correlated positively with BMI in the whole group of subjects studied (r = 0.72, P < 0.0001) and in the obese subgroup (r = 0.56, P < 0.02). No correlations could be detected between WH ratio, insulin and galanin concentrations and between galanin and BMI.
In conclusion, plasma galanin concentrations appear to be comparable in obese, normal weight and anorectic subjects. This does not exclude a role of galanin in the regulation of eating behavior since variations of the peptide in discrete brain areas may not be detectable in general circulation and peripheral sources of the peptide may contribute to its plasma levels. Also, our data suggest that galanin does not play a major role in the regulation of insulin secretion in humans.
甘丙肽被认为在饮食行为控制中发挥作用。目前尚无关于其在人类肥胖患者生物体液中浓度的信息，本研究旨在阐明这一点。
我们测量了30名肥胖女性、35名正常体重女性和11名厌食症女性的血浆甘丙肽和血清胰岛素水平。
肥胖受试者和对照受试者的甘丙肽平均水平相当（76.8±3.20对76.1±2.33 pg/ml），而厌食症患者的甘丙肽水平仅略有降低（67.9±2.30 pg/ml）。与对照组相比，肥胖患者和厌食症患者的胰岛素水平分别显著升高和降低。在整个研究的受试者组中（r = 0.72，P < 0.0001）以及肥胖亚组中（r = 0.56，P < 0.02），胰岛素与BMI呈正相关。在腰臀比、胰岛素和甘丙肽浓度之间以及甘丙肽和BMI之间未检测到相关性。
总之，肥胖、正常体重和厌食症受试者的血浆甘丙肽浓度似乎相当。这并不排除甘丙肽在饮食行为调节中的作用，因为在一般循环中可能检测不到该肽在离散脑区的变化，并且该肽的外周来源可能对其血浆水平有贡献。此外，我们的数据表明甘丙肽在人类胰岛素分泌调节中不发挥主要作用。
