Hanada H, Hino K, Fujii K, Okazaki M, Okita K
First Department of Internal Medicine, Yamaguchi University School of Medicine, Japan.
J Gastroenterol. 1995 Jun;30(3):347-50. doi: 10.1007/BF02347510.
The correlation between serum hepatitis C virus (HCV)-RNA and aminotransferase levels following completion of interferon therapy was evaluated in eight relapsed patients with chronic hepatitis C. Both HCV-RNA and aminotransferase levels were significantly increased in the relapsed patients 1 month after completion of therapy, compared to pretreatment values, despite aminotransferase levels being normal and HCV-RNA being undetectable by reverse transcription polymerase chain reaction assay at the end of therapy. The serum levels of HCV-RNA and aminotransferase were significantly elevated 1 and 2 months post-treatment. They then decreased to pretreatment values 3-5 months after the completion of therapy. Thus, in relapsed patients after the completion of therapy, the changes in HCV-RNA levels preceded the elevation in aminotransferase levels. These findings suggest a correlation between serum HCV-RNA levels and aminotransferase levels in relapsed patients with chronic hepatitis C after the completion of interferon therapy.
在8例慢性丙型肝炎复发患者中评估了干扰素治疗结束后血清丙型肝炎病毒（HCV）-RNA与转氨酶水平之间的相关性。与治疗前值相比，复发患者在治疗结束后1个月时，HCV-RNA和转氨酶水平均显著升高，尽管在治疗结束时转氨酶水平正常且通过逆转录聚合酶链反应检测法检测不到HCV-RNA。治疗后1个月和2个月时，血清HCV-RNA和转氨酶水平显著升高。然后在治疗结束后3 - 5个月降至治疗前值。因此，在治疗结束后的复发患者中，HCV-RNA水平的变化先于转氨酶水平的升高。这些发现提示慢性丙型肝炎复发患者在干扰素治疗结束后血清HCV-RNA水平与转氨酶水平之间存在相关性。
