O'Riordain M G, Ross J A, Fearon K C, Maingay J, Farouk M, Garden O J, Carter D C
University Department of Surgery, Royal Infirmary, United Kingdom.
Am J Physiol. 1995 Aug;269(2 Pt 1):E323-30. doi: 10.1152/ajpendo.1995.269.2.E323.
After trauma or sepsis, the liver undergoes a reprioritization of export protein synthesis with elevated production of some acute-phase reactants and reduced production of others. We have examined the effects of combinations of insulin and the counterregulatory hormones (dexamethasone, glucagon, and epinephrine), in the presence or absence of interleukin (IL)-6, on the production by isolated hepatocytes of the positive acute-phase proteins C-reactive protein, alpha 1-antichymotrypsin, alpha 1-acid glycoprotein, and haptoglobin, and the negative acute-phase proteins prealbumin and transferrin. The effect of IL-6 on the production of the above proteins was influenced significantly by insulin and all of the counterregulatory hormones. Significant three-way interactions as well as higher order interactions between the stress hormones and insulin were seen in the case of C-reactive protein. The results indicate that both positive and negative acute-phase proteins respond differently to insulin and the counterregulatory hormones and that the potential exists for the regulation of synthesis of individual acute-phase reactants by interaction between the cytokine network and the classical endocrine hormones.
创伤或脓毒症后，肝脏会重新调整输出蛋白的合成，一些急性期反应物的产量增加，而另一些则减少。我们研究了在有或没有白细胞介素（IL）-6的情况下，胰岛素与对抗调节激素（地塞米松、胰高血糖素和肾上腺素）联合使用对分离的肝细胞产生阳性急性期蛋白C反应蛋白、α1-抗糜蛋白酶、α1-酸性糖蛋白和触珠蛋白，以及阴性急性期蛋白前白蛋白和转铁蛋白的影响。IL-6对上述蛋白质产生的影响受到胰岛素和所有对抗调节激素的显著影响。在C反应蛋白的情况下，观察到应激激素和胰岛素之间存在显著的三向相互作用以及更高阶的相互作用。结果表明，阳性和阴性急性期蛋白对胰岛素和对抗调节激素的反应不同，并且细胞因子网络与经典内分泌激素之间的相互作用存在调节个体急性期反应物合成的潜力。
