Wagner C, Anke H, Besl H, Sterner O
LB Biotechnologie Universität, Kaiserslautern, Bundesrepublik Deutschland.
Z Naturforsch C J Biosci. 1995 May-Jun;50(5-6):358-64.
Two antimicrobial metabolites were isolated from submerged cultures of Cladobotryum rubrobrunnescens, a mycophilic fungus growing on a Inocybe species. One of the compounds proved to be identical to flavipucine (2), an antibiotic previously isolated from Aspergillus flavipes (Casinovi et al., 1968) and from a Macrophoma species (Sassa T. and Onuma Y. (1983), Agric. Biol. Chem. 47, 1155-1157). The other metabolite, brunnescin (1), is a new tetrasubstituted furan derivative which exhibits antibacterial, antifungal and cytotoxic effects.
从生长在丝盖伞属物种上的嗜温真菌红褐枝顶孢的深层培养物中分离出两种抗菌代谢物。其中一种化合物被证明与黄绿青霉素（2）相同，黄绿青霉素是一种先前从黄曲霉菌（卡西诺维等人，1968年）和一种大茎点霉属物种（笹佐T.和大沼Y.（1983年），《农业生物化学》47，1155 - 1157）中分离出的抗生素。另一种代谢物，褐菌素（1），是一种新的四取代呋喃衍生物，具有抗菌、抗真菌和细胞毒性作用。
