Jackowski A
Department of Neurosurgery, University of Birmingham, UK.
Br J Neurosurg. 1995;9(3):303-17. doi: 10.1080/02688699550041322.
In this review the author outlines the early history of clinical and scientific research upon the inability of the CNS in man to successfully regenerate following injury. As we proceed into the 21st Century we have gained a far greater understanding of the molecular biology, pathology and other factors that lead to the adult CNS being non-supportive and indeed actively inhibitory to axonal regrowth. On the basis of these recent advances in knowledge, the author outlines possible therapeutic approaches that may enable more effective CNS regeneration to be accomplished in the future.
在这篇综述中，作者概述了关于人类中枢神经系统（CNS）损伤后无法成功再生的临床和科学研究的早期历史。随着我们步入21世纪，我们对导致成年中枢神经系统不利于甚至积极抑制轴突再生的分子生物学、病理学及其他因素有了更深入的了解。基于这些最新的知识进展，作者概述了一些可能的治疗方法，这些方法未来或许能实现更有效的中枢神经系统再生。
