体细胞超突变
Somatic hypermutation.
作者信息
Neuberger M S, Milstein C
出版信息
Curr Opin Immunol. 1995 Apr;7(2):248-54. doi: 10.1016/0952-7915(95)80010-7.
PMID:7546385
Abstract
For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic features of the hypermutation, dissociated from the effects of antigenic selection.
摘要
为了产生二次免疫应答抗体，免疫球蛋白基因会发生超突变。然后通过抗原选择表达具有更高亲和力抗体的细胞。超突变机制的最新线索来自使用转基因小鼠的实验，这些实验能够分析控制超突变的顺式作用元件以及超突变的内在特征，而不受抗原选择作用的影响。
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