Sandoval L A, Giorgi W, Amaral L B, Zampolli E, Manzati M T
Arq Inst Biol (Sao Paulo). 1978 Oct-Dec;45(4):313-7.
The immuno-stimulating Levamisole action was checked by the authors in guinea-pigs vaccinated against brucellosis and exposed to the challenge test afterwards against 2.308 Brucella abortus pathogenic strain. Twelve lots of eight guinea-pigs were used disposed in the following distribution: Lots I, III, IV were vaccinated with B-19 strain vaccine; lots II, IV and VI were vaccinated with the same vaccine and, after 48 hours, received the Levamisole injection. Lots VII VIII received only the Levamisole injection and the pathogenic Brucella strain, forming the control groups. The vaccinated guinea-pigs showed a higher protection against challenge, always above 75% in relation to the lots that were only vaccinated, demonstrating a dear immuno-stimulating action of the essayed product. Considering the obtained results in this assay, the authors speculate on the anti-brucellosis vaccines potentialization with immuno-stimulating products, as Levamisole.
作者在接种了布鲁氏菌病疫苗的豚鼠身上检验了免疫刺激剂左旋咪唑的作用，之后让这些豚鼠接受针对2.308流产布鲁氏菌致病菌株的攻毒试验。使用了12组豚鼠，每组8只，分布如下：第一、三、四组用B - 19菌株疫苗接种；第二、四、六组用同一疫苗接种，48小时后注射左旋咪唑。第七、八组只注射左旋咪唑和致病布鲁氏菌菌株，作为对照组。接种疫苗的豚鼠对攻毒表现出更高的保护作用，相对于仅接种疫苗的组，保护率始终高于75%，表明所试验产品具有明显的免疫刺激作用。考虑到本次试验获得的结果，作者推测使用免疫刺激产品如左旋咪唑来增强抗布鲁氏菌病疫苗的效果。
