Zehender G, Meroni L, Piconi S, De Maddalena C, Parravicini C, Clerici M, Ridolfo A L, Moroni M, Galli M
Clinica delle Malattie Infettive, University of Milan, Italy.
AIDS Res Hum Retroviruses. 1995 Jul;11(7):823-7. doi: 10.1089/aid.1995.11.823.
We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3%-p = 0.0027). One of the HIV-1-positive and none of the HIV-1-negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-II or a closely homologous retrovirus infects a high proportion of patients with AIDS-associated NHL.
我们研究了22例艾滋病相关非霍奇金淋巴瘤（NHL）患者、453例无淋巴瘤的HIV-1感染患者（其中194例被诊断为患有艾滋病）以及6例HIV-1阳性和75例HIV-1阴性霍奇金淋巴瘤患者中抗HTLV-I/II抗体的流行情况。淋巴瘤艾滋病患者中针对HTLV抗原的血清学反应频率显著高于无淋巴瘤的患者（22例中的8例，36.4%对194例中的20例，10.3% - p = 0.0027）。1例HIV-1阳性和0例HIV-1阴性霍奇金淋巴瘤患者表现出抗HTLV-I/II反应性。在蛋白质印迹分析中进行血清学鉴别检测时，8例血清阳性的NHL患者中有4例显示出针对HTLV-II重组抗原的抗体。对研究时唯一仍存活的NHL患者的外周血单核细胞进行的PCR研究显示，基因组DNA中存在HTLV-II特异性序列。这些数据表明，HTLV-II或一种密切同源的逆转录病毒感染了很大比例的艾滋病相关NHL患者。
