在同时感染1型人类免疫缺陷病毒和2型人类嗜T淋巴细胞病毒（HTLV-2）且主要患有感觉性多神经病的患者的单核细胞/巨噬细胞谱系循环细胞中的HTLV-2前病毒。
Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy.
作者信息
Zehender G, Meroni L, Varchetta S, De Maddalena C, Cavalli B, Gianotto M, Bosisio A B, Colasante C, Rizzardini G, Moroni M, Galli M
机构信息
Istituto di Malattie Infettive e Tropicali, Università degli Studi di Milano," Milan, Italy.
出版信息
J Virol. 1998 Sep;72(9):7664-8. doi: 10.1128/JVI.72.9.7664-7668.1998.
Abstract
We investigated the presence of human T-lymphotropic virus type 2 (HTLV-2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.
摘要
我们研究了从18例同时感染1型人类免疫缺陷病毒和2型人类嗜T淋巴细胞病毒（HTLV-2）的患者中获得的外周血单个核细胞亚群中HTLV-2 DNA的存在情况，其中6例患者还患有主要为感觉性多神经病（PSP）。在CD8阳性和CD19阳性细胞中发现了HTLV-2 DNA和RNA，对于患有PSP的患者，在CD14阳性细胞中也发现了HTLV-2 DNA和RNA。此外，患有PSP的患者的前病毒载量高于未患PSP的患者。
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