Petrangeli E, Lubrano C, Ravenna L, Vacca A, Cardillo M R, Salvatori L, Sciarra F, Frati L, Gulino A
Institute of Biomedical Technology, CNR, Rome, Italy.
Br J Cancer. 1995 Oct;72(4):973-5. doi: 10.1038/bjc.1995.444.
Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic tissues, suggesting a significant role in neoplastic transformation.
对20例患者的肿瘤性和肿瘤周围乳腺组织中的雌激素受体（ER）和表皮生长因子受体（EGFR）基因甲基化情况进行了评估。在这两种组织中，ER基因甲基化与蛋白水平呈负相关，而EGFR基因甲基化则不然。在肿瘤组织中发现了ER基因优先低甲基化，提示其在肿瘤转化中起重要作用。
