Aalto-Korte K, Turpeinen M
Department of Dermatology, University Central Hospital, Helsinki, Finland.
Br J Dermatol. 1995 Aug;133(2):259-63. doi: 10.1111/j.1365-2133.1995.tb02625.x.
Percutaneous absorption of hydrocortisone was measured by determining plasma cortisol during dexamethasone suppression in 26 patients with widespread atopic dermatitis. The first and second days of treatment with applications of 1% hydrocortisone cream twice daily were studied separately in two groups of six patients. Plasma cortisol levels rose after the first two applications, reaching a maximum in 24 h. The levels then began to fall, indicating possible restoration of the skin barrier. In two other groups of seven patients, the second application was made with a cream base alone. Two types of cream base were studied, one with 60% water and the other with 30% water. With the base containing 30% water, a brief increment was seen after 2 h. On the basis of this pharmacokinetic study, treatment of acute dermatitis could be intensified by applying hydrocortisone cream twice a day on the first day, but from the second day onward one application a day seems to be sufficient.
通过在26例泛发性特应性皮炎患者的地塞米松抑制试验期间测定血浆皮质醇来测量氢化可的松的经皮吸收情况。在两组各6例患者中分别研究了每天两次外用1%氢化可的松乳膏治疗的第1天和第2天的情况。在前两次用药后血浆皮质醇水平升高，在24小时达到峰值。然后水平开始下降，表明皮肤屏障可能恢复。在另外两组各7例患者中，仅使用乳膏基质进行第二次用药。研究了两种乳膏基质，一种含60%水，另一种含30%水。对于含30%水的基质，在2小时后可见短暂升高。基于这项药代动力学研究，急性皮炎的治疗在第一天可通过每天两次外用氢化可的松乳膏来加强，但从第二天起每天一次用药似乎就足够了。
