Turpeinen M, Mashkilleyson N, Björkstén F, Salo O P
Department of Allergic Diseases, University Central Hospital, Helsinki, Finland.
Acta Derm Venereol. 1988;68(4):331-5.
Percutaneous absorption of hydrocortisone was studied in 18 young adults during and after the acute phase of atopic dermatitis using the direct hydrocortisone absorption test. In the acute phase the post-application increase in serum cortisol concentration ranged between 18 and 711 nmol/l (median 125 nmol/l). In remission the increase in serum cortisol ranged between 0 and 114 nmol/l (median 16 nmol/l), which was significantly lower than the rise in the acute phase. In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.
在18名年轻成年人的特应性皮炎急性期及缓解期，采用直接氢化可的松吸收试验研究了氢化可的松的经皮吸收情况。在急性期，涂抹后血清皮质醇浓度升高范围为18至711 nmol/l（中位数为125 nmol/l）。在缓解期，血清皮质醇升高范围为0至114 nmol/l（中位数为16 nmol/l），明显低于急性期的升高幅度。在皮炎急性期，由于经皮吸收，局部应用氢化可的松治疗具有局部和全身效应。
