Purdie D W, Empson J A, Crichton C, Macdonald L
Menopause Clinic, Princess Royal Hospital (Royal Hull Hospitals NHS Trust), Kingston Upon Hull, UK.
Br J Obstet Gynaecol. 1995 Sep;102(9):735-9. doi: 10.1111/j.1471-0528.1995.tb11433.x.
To examine the effect of hormone replacement therapy upon sleep quality and duration in postmenopausal women.
Randomised, single-blind, placebo-controlled trial.
Sleep research laboratory.
Thirty-three healthy postmenopausal women.
Continuous 0.625 mg conjugated equine oestrogens with 0.15 mg cyclic norgestrel taken for 12 days per 28 day cycle.
Occurrence of vasomotor symptoms, polysomnographic sleep stage measures, Stanford sleepiness questionnaire, Crown-Crisp experiential index and the cognitive failures questionnaire.
Hormone replacement therapy results in an improvement in menopausal symptoms but not in parameters of sleep quality. Despite this, certain measures of psychological wellbeing showed significant improvement in the hormone replacement therapy group.
Hormone replacement therapy results in a measurable improvement in physical and psychological welfare, the latter being independent of improvement in sleep quality.
研究激素替代疗法对绝经后女性睡眠质量和时长的影响。
随机、单盲、安慰剂对照试验。
睡眠研究实验室。
33名健康的绝经后女性。
每28天周期中连续12天服用0.625毫克结合马雌激素与0.15毫克周期性炔诺酮。
血管舒缩症状的发生情况、多导睡眠图睡眠阶段测量、斯坦福嗜睡问卷、克朗-克里斯普体验指数和认知失误问卷。
激素替代疗法可改善绝经症状，但对睡眠质量参数无改善作用。尽管如此，激素替代疗法组的某些心理健康指标显示有显著改善。
激素替代疗法可显著改善身体和心理状况，心理状况的改善独立于睡眠质量的改善。
