Jahnson S, Graf W, Rikner G, Gerdin B
Department of Urology, Orebro Medical Center, Sweden.
Eur J Surg. 1995 Jun;161(6):425-30.
To assess the influence of chronic radiation damage on anastomotic healing in the small bowel in rats.
Controlled laboratory study.
University hospital, Sweden.
90 male Sprague-Dawley rats.
A short segment of the distal ileum was exteriorised and irradiated with a single dose (experimental group, n = 45) or exposed only (control group, n = 45). Twenty weeks later resection and anastomosis were done within this segment using 7/0 polypropylene.
The anastomotic breaking strength, the amount of perianastomotic hydroxyproline, and the number of anastomotic complications.
The breaking strength and the amount of perianastomotic hydroxyproline were higher in the irradiated than in the non-irradiated group. In contrast, anastomotic complications were significantly more common in irradiated animals.
Anastomotic complications in irradiated intestine are not related to the amount of perianastomotic collagen or to breaking strength.
评估慢性辐射损伤对大鼠小肠吻合口愈合的影响。
对照实验室研究。
瑞典大学医院。
90只雄性斯普拉格-道利大鼠。
将一段远端回肠外置，对其中一组（实验组，n = 45）给予单次剂量照射，另一组（对照组，n = 45）仅作暴露处理。20周后，在该肠段内用7/0聚丙烯进行切除和吻合。
吻合口断裂强度、吻合口周围羟脯氨酸含量及吻合口并发症数量。
照射组的断裂强度和吻合口周围羟脯氨酸含量高于未照射组。相比之下，照射动物的吻合口并发症明显更为常见。
受照射肠段的吻合口并发症与吻合口周围胶原蛋白含量或断裂强度无关。
