Katabami S, Sugiyama T, Kodama T, Kamijo K, Azuma N, Tamaki T, Katanuma A, Fujisawa Y, Kinoshita H, Imai K
Department of Internal Medicine, Muroran City General Hospital.
Intern Med. 1995 Jun;34(6):569-73. doi: 10.2169/internalmedicine.34.569.
A 53-year-old woman with polymyositis associated with thymoma subsequently developed pure red cell aplasia (PRCA). She was hospitalized because of fever and muscle weakness, and diagnosed as having polymyositis by muscle biopsy. Remarkable clinical improvement followed administration of prednisolone. Progressive anemia became evident, however, while prednisolone was being tapered. Erythroid aplasia and the presence of thymoma confirmed the diagnosis of PRCA. Further examinations revealed that cytotoxic T cells may play an important role in the pathogenesis of this case.
一名53岁患有与胸腺瘤相关的多发性肌炎的女性随后发展为纯红细胞再生障碍性贫血（PRCA）。她因发热和肌肉无力住院，经肌肉活检诊断为多发性肌炎。给予泼尼松龙后临床症状显著改善。然而，在逐渐减少泼尼松龙用量时，进行性贫血变得明显。红细胞生成障碍和胸腺瘤的存在证实了PRCA的诊断。进一步检查显示，细胞毒性T细胞可能在该病例的发病机制中起重要作用。
