McInnes L A, Freimer N B
Department of Psychiatry, University of California San Francisco 94143, USA.
Curr Opin Genet Dev. 1995 Jun;5(3):376-81. doi: 10.1016/0959-437x(95)80054-9.
In the past year, some of the most exciting findings in the genetic investigation of mammalian behavior have been obtained through mapping and through gene manipulation studies in the mouse system. These include the localization of a gene for circadian periodicity in the mouse, gene knockouts of serotonin receptors, and the development of a transgenic model of Alzheimer's disease. The recent development of genetic maps covering the entire human genome and the implementation of new approaches to genetic analysis may now facilitate elucidation of complex behaviors in humans, particularly psychiatric disorders.
在过去的一年里，通过在小鼠系统中的图谱绘制和基因操作研究，在哺乳动物行为的基因研究中取得了一些最令人兴奋的发现。这些发现包括小鼠昼夜节律基因的定位、血清素受体的基因敲除以及阿尔茨海默病转基因模型的开发。覆盖整个人类基因组的遗传图谱的最新进展以及遗传分析新方法的应用，现在可能有助于阐明人类的复杂行为，尤其是精神疾病。
