Ho C S, Lin S P, Shen E Y, Chiu N C
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan ROC.
J Formos Med Assoc. 1995 Jul;94(7):414-7.
Dental enamel pitting was studied as a diagnostic sign of pediatric tuberous sclerosis (TSC). Thirteen patients aged 2.5 to 18 years with varying degrees of TSC were evaluated. They were checked for the presence of enamel pitting by the use of two to three drops of dental plaque disclosing stain which was applied to the labial surfaces of dry teeth. This technique provides a remarkable color contrast allowing for the detection of many small and subtle enamel pits. A control group of 39 unrelated patients without TSC were also examined. A total of 77% of TSC patients (10/13) revealed enamel pitting, compared with 13% of controls. The distribution of enamel pitting among TSC patients and normal controls of each sex was statistically significant. The total number of enamel pits in each patient varied from 1 to 26 and increased with age; 90% of the teeth with enamel pitting displayed one to two pits per tooth. The youngest patient with enamel pitting was 5 years old. The simplicity of this test and the high probability of pitting in TSC make the examination useful in the assessment of patients in whom the diagnosis of this serious genetic disease is being considered.
研究了牙釉质凹陷作为小儿结节性硬化症（TSC）的诊断标志。对13例年龄在2.5至18岁之间、患有不同程度TSC的患者进行了评估。通过在干燥牙齿的唇面滴两到三滴牙菌斑显示染色剂来检查是否存在牙釉质凹陷。该技术提供了显著的颜色对比，有助于检测许多小而细微的牙釉质凹陷。还对39名无TSC的无关患者组成的对照组进行了检查。77%的TSC患者（10/13）出现牙釉质凹陷，而对照组为13%。牙釉质凹陷在TSC患者和各性别正常对照中的分布具有统计学意义。每位患者的牙釉质凹陷总数从1至26个不等，并随年龄增加；90%有牙釉质凹陷的牙齿每颗有一到两个凹陷。最年轻的有牙釉质凹陷的患者为5岁。该检测方法简单，且TSC患者出现凹陷的可能性高，这使得该检查在评估疑似患有这种严重遗传病的患者时很有用。
