肺炎衣原体是无症状老年男性患冠心病的一个风险因素，但幽门螺杆菌和巨细胞病毒不是。
Chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but Helicobacter pylori and cytomegalovirus are not.
作者信息
Ossewaarde J M, Feskens E J, De Vries A, Vallinga C E, Kromhout D
机构信息
Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
出版信息
Epidemiol Infect. 1998 Feb;120(1):93-9. doi: 10.1017/s0950268897008303.
To test the hypothesis that chronic infection with Chlamydia pneumoniae, Helicobacter pylori or cytomegalovirus is associated with coronary heart disease risk in elderly men, a nested case-control study in a cohort investigated in 1985 and 1990 in the town of Zutphen, The Netherlands, was designed. Fifty-four cases with a first diagnosed coronary event between 1985 and 1990, and 108 age-matched control subjects free of coronary heart disease during follow up were included in the study. The overall prevalence of antibodies to cytomegalovirus was 74.7%, to H. pylori 75.9% and to C. pneumoniae 84.0%. A high level of antibodies to C. pneumoniae was associated with an increased coronary heart disease risk (OR = 2.76; 95% CI = 1.31-5.81). This association was stronger in cases developing both myocardial infarction and angina pectoris, than in cases developing only one of these. This association was independent of potential confounders. Antibodies to cytomegalovirus or H. pylori were not associated with coronary heart disease risk. These results support the hypothesis of a role of chronic C. pneumoniae infections in the immunopathogenesis of atherosclerosis.
为了验证肺炎衣原体、幽门螺杆菌或巨细胞病毒的慢性感染与老年男性冠心病风险相关这一假设，在荷兰祖特芬镇于1985年和1990年开展的一项队列研究中设计了一项巢式病例对照研究。该研究纳入了1985年至1990年间首次诊断为冠心病事件的54例患者，以及随访期间无冠心病的108例年龄匹配的对照受试者。巨细胞病毒抗体的总体患病率为74.7%，幽门螺杆菌抗体为75.9%，肺炎衣原体抗体为84.0%。高水平的肺炎衣原体抗体与冠心病风险增加相关（比值比=2.76；95%置信区间=1.31-5.81）。这种关联在同时发生心肌梗死和心绞痛的病例中比仅发生其中一种情况的病例中更强。这种关联独立于潜在的混杂因素。巨细胞病毒或幽门螺杆菌抗体与冠心病风险无关。这些结果支持了慢性肺炎衣原体感染在动脉粥样硬化免疫发病机制中起作用的假设。
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