Buscombe J R, Oyen W J, Corstens F H
Department of Nuclear Medicine, Royal Free Hospital, London, UK.
Q J Nucl Med. 1995 Sep;39(3):212-20.
Nuclear Medicine should have a pivitol role to play in the investigation of patients infected with the human immunodeficiency virus (HIV). Unfortunately the use of scintigraphic techniques to localise infection have not become widely used in Europe. Neither 67Ga citrate or labelled leukocytes are ideal. In a search for new agents which can be used to identify the presence of infection both 99mTc and 111In labelled polyclonal immunoglobulin-C have been investigated. It was found that 99mTc labelled polyclonal immune-globulin-G was not able to localise infection in either the chest or the abdomen. In contrast 111In labelled polyclonal immunoglobulin-G had both high sensitivity and specificity for imaging infection in HIV infected patients. If these preliminary results are confirmed immunoglobulin-G could find an important clinical application in this specialised patient group.
核医学在对感染人类免疫缺陷病毒（HIV）的患者进行检查方面应发挥关键作用。遗憾的是，用于定位感染的闪烁显像技术在欧洲尚未得到广泛应用。枸橼酸镓67或标记白细胞都不理想。为寻找可用于识别感染存在的新型制剂，人们对99m锝和111铟标记的多克隆免疫球蛋白-C进行了研究。结果发现，99m锝标记的多克隆免疫球蛋白-G无法在胸部或腹部定位感染。相比之下，111铟标记的多克隆免疫球蛋白-G对HIV感染患者的感染成像具有高敏感性和特异性。如果这些初步结果得到证实，免疫球蛋白-G可能会在这个特殊患者群体中找到重要的临床应用。
