Sangal R B, Sangal J M, Belisle C
Sleep Disorders Institute, Troy, Michigan, USA.
Clin Electroencephalogr. 1999 Jan;30(1):28-32. doi: 10.1177/155005949903000111.
To compare auditory and visual P300 amplitude and latency magnitudes and topographies in patients with narcolepsy and normal subjects, 20 patients with polysomnographically-confirmed narcolepsy and 40 normal subjects were administered auditory and visual P300 testing using 31 evenly spaced scalp electrodes. Patients with narcolepsy were then administered baseline polysomnograms and objective (MSLT, Maintenance of Wakefulness Test or MWT) and subjective tests (Epworth Sleepiness Scale, Clinical Global Impression) of daytime sleepiness. Patients had longer 31-electrode mean age-adjusted auditory P300 latencies (406.0 +/- 27.8 vs. 385.7 +/- 28.9 ms, p = 0.012) and visual P300 latencies (427.3 +/- 29.0 vs. 411.4 +/- 27.7 ms., p = 0.044) than 40 normal subjects in the same age range. Age-adjusted auditory P300 latency was correlated with MWT (r = -0.49, p = 0.028), but not with any other clinical variable or measure of sleepiness. Age-adjusted visual P300 latency was not correlated with any clinical variable or measure of sleepiness. Patients with narcolepsy had longer auditory and visual P300 latencies than normal subjects.
为比较发作性睡病患者与正常受试者的听觉和视觉P300波幅、潜伏期大小及地形图，对20例经多导睡眠图确诊的发作性睡病患者和40名正常受试者使用31个等间距头皮电极进行听觉和视觉P300测试。随后对发作性睡病患者进行基线多导睡眠图检查以及白天嗜睡的客观测试（多导睡眠监测仪、清醒维持测试或MWT）和主观测试（爱泼华嗜睡量表、临床总体印象）。与同一年龄范围的40名正常受试者相比，发作性睡病患者的31电极平均年龄校正听觉P300潜伏期更长（406.0±27.8 vs. 385.7±28.9毫秒，p = 0.012），视觉P300潜伏期也更长（427.3±29.0 vs. 411.4±27.7毫秒，p = 0.044）。年龄校正听觉P300潜伏期与MWT相关（r = -0.49，p = 0.028），但与任何其他临床变量或嗜睡测量指标均不相关。年龄校正视觉P300潜伏期与任何临床变量或嗜睡测量指标均不相关。发作性睡病患者的听觉和视觉P300潜伏期比正常受试者更长。
