阻塞性睡眠呼吸暂停与 P300 诱发电位
Obstructive sleep apnea and P300 evoked auditory potential.
机构信息
Depto de Fonoaudiologia, Fac de Odontologia, UNESP.
出版信息
Braz J Otorhinolaryngol. 2011 Nov-Dec;77(6):700-5. doi: 10.1590/S1808-86942011000600004.
UNLABELLED
The obstructive sleep apnea syndrome (OSAS) reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction.
OBJECTIVE
To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients.
MATERIALS AND METHODS
Prospective study with primary snorers (N=12) and in OSAS patients (N=54), submitted to polysomnography, defined by the apnea-hypopnea index (AHI). The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance level of 5%.
RESULTS
AIH had an inverse correlation with the oximetry in both groups. The P300 prevalence was lower in the OSAS group (Fisher's Exact Test, p=0.027). Patient age did not influence the P300 prevalence (regression analysis; p=0.232). The P300 amplitude was lower in the OSAS group (t-Student test; p=0.003) and the P300 latency was similar in both groups (t-Student test; p=0.89).
CONCLUSION
The reduction in the P300 amplitude in patients with OSAS suggests cognitive dysfunction induced by a reduction in auditory memory.
未加标签
阻塞性睡眠呼吸暂停综合征（OSAS）会降低注意力、记忆力和集中力，这些都与认知能力有关。听觉 P300 参数的分析可以帮助推断认知功能障碍。
目的
比较原发性打鼾者和 OSAS 患者的多导睡眠图和听觉 P300 数据。
材料和方法
前瞻性研究纳入了原发性打鼾者（N=12）和 OSAS 患者（N=54），他们均接受了多导睡眠图检查，通过呼吸暂停低通气指数（AHI）来定义 OSAS。使用 t-Student 检验、确切 Fisher 检验、逻辑回归和相关性分析比较多导睡眠图和 P300 变量，显著性水平为 5%。
结果
AIH 在两组中均与血氧饱和度呈负相关。OSAS 组的 P300 发生率较低（Fisher 确切检验，p=0.027）。患者年龄不影响 P300 发生率（回归分析；p=0.232）。OSAS 组的 P300 波幅较低（t-Student 检验；p=0.003），两组的 P300 潜伏期相似（t-Student 检验；p=0.89）。
结论
OSAS 患者的 P300 波幅降低表明听觉记忆减少导致认知功能障碍。
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