Oren R, Hilzenrat N, Maaravi Y, Yaari A, Sikuler E
Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Dig Dis Sci. 1995 Sep;40(9):1941-5. doi: 10.1007/BF02208661.
Portal hypertension is accompanied by a hyperdynamic circulatory state that shares some similarities with thyrotoxicosis. This study was conducted in order to investigate the hemodynamic effects of hypothyroidism in a rat model with portal hypertension induced by partial portal vein ligation (PVL). Four groups of 10 rats each were studied: normal control and hypothyroid rats, and PVL control and hypothyroid rats. Hypothyroidism was induced by methimazole 0.04% in drinking water. Hemodynamic measurements were performed using the radioactive microsphere technique. Induction of hypothyroidism was confirmed by elevated TSH levels. In the PVL groups, hypothyroidism ameliorated the hyperdynamic circulation. Portal venous inflow and portal pressure dropped significantly: 7.1 +/- 0.2 vs 4.8 +/- 0.3 ml/min/100 g body wt (P < 0.01) and 13.4 +/- 0.9 vs 10.9 +/- 0.8 mm Hg; (P < 0.01), respectively. In normal rats, hypothyroidism was manifested by a hypodynamic circulatory state. These results demonstrate that hypothyroidism induced by methimazole is followed by amelioration of the hyperdynamic circulation, normalization of portal venous inflow, and reduction of portal pressure.
门静脉高压伴有高动力循环状态，这与甲状腺毒症有一些相似之处。本研究旨在探讨在部分门静脉结扎（PVL）诱导的门静脉高压大鼠模型中甲状腺功能减退的血流动力学效应。研究了四组大鼠，每组10只：正常对照组和甲状腺功能减退大鼠组，以及PVL对照组和甲状腺功能减退大鼠组。通过在饮用水中添加0.04%的甲巯咪唑诱导甲状腺功能减退。使用放射性微球技术进行血流动力学测量。通过促甲状腺激素水平升高证实甲状腺功能减退的诱导。在PVL组中，甲状腺功能减退改善了高动力循环。门静脉流入量和门静脉压力显著下降：分别为7.1±0.2与4.8±0.3 ml/min/100 g体重（P<0.01）和13.4±0.9与10.9±0.8 mmHg；（P<0.01）。在正常大鼠中，甲状腺功能减退表现为低动力循环状态。这些结果表明，甲巯咪唑诱导的甲状腺功能减退后，高动力循环得到改善，门静脉流入量恢复正常，门静脉压力降低。
